Abstract
A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP).
MeSH terms
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Amino Acid Sequence
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Bone Morphogenetic Protein 1
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Bone Morphogenetic Proteins / antagonists & inhibitors*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Hydroxamic Acids / chemical synthesis*
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Hydroxamic Acids / chemistry
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Hydroxamic Acids / pharmacology
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Metalloendopeptidases / antagonists & inhibitors*
Substances
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Bone Morphogenetic Proteins
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Enzyme Inhibitors
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Hydroxamic Acids
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Metalloendopeptidases
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Bone Morphogenetic Protein 1