Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase

Bioorg Med Chem Lett. 2000 Nov 20;10(22):2513-6. doi: 10.1016/s0960-894x(00)00525-4.

Abstract

A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP).

MeSH terms

  • Amino Acid Sequence
  • Bone Morphogenetic Protein 1
  • Bone Morphogenetic Proteins / antagonists & inhibitors*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Hydroxamic Acids / chemical synthesis*
  • Hydroxamic Acids / chemistry
  • Hydroxamic Acids / pharmacology
  • Metalloendopeptidases / antagonists & inhibitors*

Substances

  • Bone Morphogenetic Proteins
  • Enzyme Inhibitors
  • Hydroxamic Acids
  • Metalloendopeptidases
  • Bone Morphogenetic Protein 1